Ntn1 (基因名), Netrin-1 (蛋白名), net1_mouse.
通用注释
亚单元:
Binds to its receptors; DCC, UNC5A, UNC5B, UNC5C and probably UNC5D (By similarity). Binds to its receptor; DSCAM.
功能:
Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in colorectal tumorigenesis by regulating apoptosis.
亚细胞位置:
Secreted
Extracellular space
Extracellular matrix
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