Slc2a4 (基因名), Solute carrier family 2, facilitated glucose transporter member 4 (蛋白名), glut4_rat.
产品名称:
Rat Slc2a4/ Solute carrier family 2, facilitated glucose transporter member 4 CLIA Kit
溶质运载蛋白家族2葡萄糖转运蛋白4
货号:
U2023r
商标:
EIAab®
监管等级:
别名:
Glucose transporter type 4, insulin-responsive, GLUT-4, Glut4
检测方法:
CLIA
实验类型:
Sandwich
检测范围:
19.5-1250pg/mL
特异性:
Natural and recombinant rat Solute carrier family 2, facilitated glucose transporter member 4
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
-
通用注释
亚单元:
Binds to DAXX. Interacts via its N-terminus with SRFBP1 (By similarity). Interacts with NDUFA9 (PubMed:16396496). Interacts with TRARG1; the interaction is required for proper SLC2A4 recycling after insulin stimulation (By similarity).
功能:
Insulin-regulated facilitative glucose transporter, which plays a key role in removal of glucose from circulation (PubMed:2649253, PubMed:2645527, PubMed:2211693). Response to insulin is regulated by its intracellular localization: in the absence of insulin, it is efficiently retained intracellularly within storage compartments in muscle and fat cells (PubMed:2649253, PubMed:2645527, PubMed:2211693). Upon insulin stimulation, translocates from these compartments to the cell surface where it transports glucose from the extracellular milieu into the cell (PubMed:2649253, PubMed:2645527, PubMed:2211693).
亚细胞位置:
Cell membrane
Multi-pass membrane protein
Endomembrane system
Multi-pass membrane protein
Cytoplasm
Perinuclear region
Localizes primarily to the perinuclear region, undergoing continued recycling to the plasma membrane where it is rapidly reinternalized (By similarity). The dileucine internalization motif is critical for intracellular sequestration (By similarity). Insulin stimulation induces translocation to the cell membrane (PubMed:2211693).
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