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  IF  :   36.216
SummaryThere is considerable inter-individual variability in susceptibility to weight gain despite an equally obesogenic environment in large parts of the world. Whereas many studies have focused on identifying the genetic susceptibility to obesity, we performed a GWAS on metabolically healthy thin individuals lowest 6...
M Orthofer, A Valsesia, J Kaczanowska, et al.
Source: Cell
  IF  :   3.385
AbstractThis study was intended to demonstrate that prenatal dexamethasone exposure PDE can induce low basal activity of the hypothalamic-pituitary-adrenal axis HPAA in male offspring rats and explore the underlying mechanism. Pregnant rats were subcutaneously administered 0.2 mgkgd dexamethasone from gestational day G...
J Lu, Q Li, D Xu, et al.
Source: Toxicology Letters
  IF  :   3.548
AbstractThe relationship between microRNA miR and immune activity in allergic rhinitis AR remains unclear. 37 children with AR and 30 healthy children were enrolled to study the correlation of miR-223 and IL-35. There was a significant inverse correlation between plasma levels of IL-35 and serum eosinophil cationic pro...
GX Ruan, Xl Wen, Zw Yuan, et al.
Source: Clinical Immunology
  IF  :   3.17
AbstractOlmesartan OLM, an angiotensin receptor blocker, was tested against diabetesinsulin resistance IR models associated with renalcardiovascular complications. Methods: we tested its potential role against diabetes-induced hepatic hitches using an IRtype2 diabetic IRD model induced by high fathigh fructose diet for...
D O Saleh, S S. Mahmoud, S M. Nofal, et al.
Source: European Journal of Pharmacology
  IF  :   3.775
AbstractThis study was designed to demonstrate that prenatal ethanol exposure PEE can induce low functional expression of the hypothalamus in male offspring rats and explore the underlying mechanism. Pregnant rats were administered 4 gkg ethanol or normal saline by oral gavage each day from gestational day GD 9 to GD20...
J Lu, Q Li, GQ Ma, et al.
Source: Food and Chemical Toxicology
  IF  :   5.352
AbstractThis study investigated the influences of titanium dioxide nanoparticles n-TiO2 on the thyroid endocrine disruption and neurobehavioral defects induced by pentachlorophenol PCP in zebrafish Danio rerio. Embryos 2 h post-fertilization were exposed to PCP 0, 3, 10, and 30 μgL or in combination with n-TiO2 0.1 mgL...
L Lei, K Qiao, J Han, et al.
Source: Chemosphere
  IF  :   4.60
AbstractThis study aimed to evaluate renal morphology and the renal renin-angiotensin system in 6- and 81-day-old male and female offspring exposed to zinc deficiency during fetal life, lactation andor postnatal growth. Female Wistar rats were fed low- or control zinc diets from pregnancy to offspring weaning. Afterwar...
C Caniffi, L Veiras, R Elesgaray, et al.
Source: The Journal of Nutritional Biochemistry
  IF  :   2.697
AbstractCadmium is a common heavy metal pollutant. Previous studies have found that long-term cadmium exposure can cause damage to multiple organssystems in humans and experimental animals; however, there are few studies that elucidate its effects on offspring development, discuss whether it can be transmitted to offsp...
JJ Tian, J Hu, W He, et al.
Source: Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology
  IF  :   3.531
AbstractBackgroundSeptic encephalopathy, the most frequent complication of sepsis, is orchestrated by a complex interplay of signals that leads to high mortality rates among intensive care unit patients. However, the role of the vascular endothelial growth factor receptor-2 VEGFR2 in endoplasmic reticulum stress respon...
D A. Zaky, W Wadie, W M. Eldehna, et al.
Source: Life Sciences
  IF  :   3.531
ABSTRACTAims: Lipopolysaccharide LPS-induced intestinal injury is a common clinical feature of sepsis. Aggravated inflammation and higher sensitivity to infection are associated with high-fat diet HFD in patients with type 2 diabetes andor obesity. However, the mechanism by which HFD exacerbates LPS-induced intestinal i...
S Hu, LJ Pan, HF Liao, et al.
Source: Life Sciences
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