首页 > 重组蛋白 > Human DYNLL1 Recombinant Protein

DYNLL1 (基因名), Dynein light chain 1, cytoplasmic (蛋白名), dyl1_human.

产品名称:

Human DYNLL1/ Dynein light chain 1, cytoplasmic Recombinant Protein
动力蛋白轻链1，细胞质

货号:

R13866h

商标:

EIAab^®

监管等级:

RUO

别名:

8 kDa dynein light chain, Dynein light chain LC8-type 1, Protein inhibitor of neuronal nitric oxide synthase, DLC8, PIN, DLC1, DNCL1, DNCLC1, HDLC1

序列号:

P63167

来源:

E.coli

种属:

Human

标签:

His

纯度:

>90% by SDS-PAGE

浓度:

Reconstitution Dependent

形态:

Liquid

内毒素水平:

Please contact protein@eiaab.com The technician for more information.

应用:

存储缓冲液:

50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)

存储:

Store at -20°C. (Avoid repeated freezing and thawing.)

研究领域:

Cancer

规格 & 价格:

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Human DYNLL1 Protein

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产品说明书

说明书:

MSDS:

在线询价

数据
文献
出版物
序列 / 3D
常见问题解答
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R&D 技术数据

更多信息，请参阅手册，或联系我们的技术支持: tech@eiaab.com.

基因位点

Cytogenetic band: 12q24.31 by HGNC 12q24.31 by Entrez Gene 12q24.31 by Ensembl

DYNLL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

通用注释

亚单元:

Homodimer. Monomer; the monomeric form is incapable of binding to target proteins. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Interacts with rabies P protein (By similarity). Interacts with TXNDC17. Interacts with WWC1 and ESR1. The WWC1-DYNLL1 interaction is mandatory for the recruitment and transactivation functions of ESR1 or DYNLL1 to the target chromatin. Interacts with BCL2L11 isoform 1 and isoform 2. Interacts with BCL2; the interaction is greatly enhanced in the nucleus and in mitochondria upon induction of apoptosis. Interacts with PAK1; the interaction requires dimeric DYNLL1. Interacts with human spumaretrovirus Gag protein; this interaction is critical for intracellular microtubule-dependent viral genome transport toward the centrosome. Interacts with MYZAP. Part of an astrin (SPAG5)-kinastrin (SKAP) complex containing KNSTRN, SPAG5, PLK1, DYNLL1 and SGO2. Interacts with ATMIN; this interaction inhibits ATMIN transcriptional activity and hence may play a role in a feedback loop whereby DYNLL1 inhibits transactivation of its own promoter by ATMIN. Interacts with NEK9 (not phosphorylated at 'Ser-944'). Interacts with BICD2.

功能:

Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules. Upon apoptotic stimuli the BCL2L11-DYNLL1 complex dissociates from cytoplasmic dynein and translocates to mitochondria and sequesters BCL2 thus neutralizing its antiapoptotic activity.

亚细胞位置:

Cytoplasm Cytoskeleton Nucleus Mitochondrion Upon induction of apoptosis translocates together with BCL2L11 to mitochondria.

数据库链接

UniGene:

Hs.5120

SMR:

P63167

STRING:

9606.ENSP00000242577

KEGG:

hsa:8655

MIM:

601562

Pfam:

PF01221

Uniprot:

P63167

相关产品

Mouse Dynll1 ELISA Kit

Rat Dynll1 ELISA Kit

Bovine DYNLL1 ELISA Kit

Mouse Dynll1 CLIA Kit

Rat Dynll1 CLIA Kit

序列长度:

序列:

仅供参考，详细请咨询（services@eiaab.com）

50:

89:

NPTWHCIVGR | NFGSYVTHET | KHFIYFYLGQ | VAILLFKSG

3D 模型:

3D 结构:

免疫原序列:

验证序列:

该产品尚未在任何出版物中被引用。

[1].

"Serine 88 phosphorylation of the 8-kDa dynein light chain 1 is a molecular switch for its dimerization status and functions."

(PMID: 18084006)

[2].

"Dynein light chain 1, a p21-activated kinase 1-interacting substrate, promotes cancerous phenotypes."

(PMID: 15193260)

[3].

"The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex."

(PMID: 10198631)

[4].

"Structure of the PIN/LC8 dimer with a bound peptide."

(PMID: 10426949)

[5].

"Cytoplasmic dynein (ddlc1) mutations cause morphogenetic defects and apoptotic cell death in Drosophila melanogaster."

(PMID: 8628263)

[6].

"Structural analysis of the regulation of the DYNLL/LC8 binding to Nek9 by phosphorylation."

(PMID: 23482567)

[7].

"ATM substrate Chk2-interacting Zn2+ finger (ASCIZ) Is a bi-functional transcriptional activator and feedback sensor in the regulation of dynein light chain (DYNLL1) expression."

(PMID: 22167198)

[8].

"Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score."

(PMID: 20379614)

[9].

"Structural basis for the interaction between dynein light chain 1 and the glutamate channel homolog GRINL1A."

(PMID: 20412299)

[10].

"Biochemical and structural characterization of the Pak1-LC8 interaction."

(PMID: 18650427)

[1].

人动力蛋白轻链1，细胞质(DYNLL1)重组蛋白是否是无菌的？

蛋白试剂瓶和蛋白保存液是经过高压灭菌的，但也不能保证蛋白是完全无菌的。如果要求蛋白是无菌的，可以用0.2微米的滤器对蛋白进行过滤。

[2].

人动力蛋白轻链1，细胞质(DYNLL1)重组蛋白的保存缓冲液是什么？

纯化后的蛋白保存在PBS（58mM Na2HPO4, 17mM NaH2PO4, 68mM NaCl, pH7.4）里，并往里面加入500mM咪唑和10%甘油。

[3].

怎样确定人动力蛋白轻链1，细胞质(DYNLL1)重组蛋白的浓度？

蛋白浓度的确定没有一个统一的标准，这主要取决于蛋白的氨基酸序列。伊艾博是根据不同测试的组合来测定蛋白浓度。考马斯亮蓝法、BCA法、氨基酸序列和氨基酸全序列分析法等都用来测定蛋白浓度。

[4].

人动力蛋白轻链1，细胞质(DYNLL1)重组蛋白蛋白保存条件是怎样的？

蛋白应保存在 -20℃或 -80℃条件下，为了避免反复冻融，可以将蛋白分装成小份保存。

[5].

人动力蛋白轻链1，细胞质(DYNLL1)重组蛋白是否可以用于活体实验？

重组蛋白没有用于任何的活体实验，因此蛋白的活性和半衰期是不确定的。

[6].

人动力蛋白轻链1，细胞质(DYNLL1)重组蛋白的保质期是多久？

在适当的保存条件下，从购买之日起蛋白可以稳定保存6-12个月。适当的保存条件是:蛋白保存在-20°C o或 -80℃，保证蛋白的保存浓度高于0.1mg/ml，限制蛋白反复冻融的次数。我们公司常规的质量检测保证所有产品在销售时都有可接受的生物活性。但是我们不能控制终端用户蛋白的保存条件。如果产品在有效期内出现问题，请联系我们的技术支持。

[7].

你们蛋白和抗体的报价是怎么样的？

我们将根据你需要的蛋白和抗体的大小进行报价。

[8].

人动力蛋白轻链1，细胞质(DYNLL1)重组蛋白是否能够提供蛋白片段？

我们现有的人的蛋白的序列可以有很多。你可以选择你感兴趣的靶向部分，我们将会按您的需求提供蛋白和抗体。

[9].

人动力蛋白轻链1，细胞质(DYNLL1)重组蛋白的货期或发货时间一般是多长？

具体指标的货期需要确定。最快一周，最长可能一个月。

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