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CD274 (基因名), Programmed cell death 1 ligand 1 (蛋白名), pd1l1_human.
产品名称:

Human CD274/ Programmed cell death 1 ligand 1 Recombinant Protein
程序性死亡配体-1

货号:

R0513h

商标:
EIAab®
监管等级:
别名:

B7 homolog 1, B7-H1, CD274, PD-L1, B7H1, PDCD1L1, PDCD1LG1, PDL1

序列号:
Q9NZQ7
来源:
E.coli
种属:
Human
标签:
His
序列:
19-290aa
预估分子量:
29.92 kDa (monomer)
纯度:
Greater than 95% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
  • Human CD274 Protein
  • Human CD274 Protein
  • Human CD274 Protein
规格 & 价格: cart
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Human CD274 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
Human CD274 Protein
The PCR product of human CD274 gene was determined by 1% Agarose stained with EB.
Human CD274 Protein
Recombinant human CD274 protein was determined by 12% SDS-PAGE stained with Coomassie Blue under reducing conditions.
基因位点
Cytogenetic band: 9p24.1 by HGNC 9p24.1 by Entrez Gene 9p24.1 by Ensembl
CD274 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Interacts with PDCD1.


功能:
Involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production.


亚细胞位置:
Isoform 2 Endomembrane system Single-pass type I membrane protein



[1].
"Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation."

[2].
"Programmed death ligand 1 (PD-L1) gene variants contribute to autoimmune Addison's disease and Graves' disease susceptibility."

[3].
"Association of an A/C single nucleotide polymorphism in programmed cell death-ligand 1 gene with Graves' disease in Japanese patients."

[4].
"Identification of a novel splice variant of human PD-L1 mRNA encoding an isoform-lacking Igv-like domain."

[5].
"B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion."
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