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BACE1 (基因名), Beta-secretase 1 (蛋白名), bace1_human.
产品名称:

Human BACE1/ Beta-secretase 1 Recombinant Protein
β分泌酶1

货号:

R0718h

商标:
EIAab®
监管等级:
别名:

Aspartyl protease 2, Beta-site amyloid precursor protein cleaving enzyme 1, Memapsin-2, Membrane-associated aspartic protease 2, ASP2, Beta-site APP cleaving enzyme 1, BACE, KIAA1149

序列号:
P56817
来源:
E.coli
种属:
Human
标签:
His
序列:
42-195aa
预估分子量:
16.94 kDa (monomer)
纯度:
Greater than 95% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Neurosciences
  • Human BACE1 Protein
  • Human BACE1 Protein
  • Human BACE1 Protein
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Human BACE1 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
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R&D 技术数据
Human BACE1 Protein
The PCR product of human BACE1 gene was determined by 1% Agarose stained with EB.
Human BACE1 Protein
Recombinant human BACE1 protein was determined by 12% SDS-PAGE stained with Coomassie Blue under reducing conditions.
基因位点
Cytogenetic band: 11q23.3 by HGNC 11q23.3 by Entrez Gene 11q23.3 by Ensembl
BACE1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Monomer. Interacts (via DXXLL motif) with GGA1, GGA2 and GGA3 (via their VHS domain); the interaction highly increases when BACE1 is phosphorylated at Ser-498 (PubMed:14567678, PubMed:15886016). Interacts with RTN3 and RTN4 (PubMed:15286784, PubMed:16965550, PubMed:16979658). Interacts with SNX6 (PubMed:20354142). Interacts with PCSK9 (PubMed:18660751). Interacts with NAT8 and NAT8B (PubMed:19011241). Interacts with BIN1 (PubMed:27179792). Interacts (via extracellular domain) with ADAM10 (via extracellular domain) (By similarity). Interacts with SORL1; this interaction may affect binding with APP and hence reduce APP cleavage (PubMed:16407538).


功能:
Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase (PubMed:10656250, PubMed:10677483, PubMed:20354142). Cleaves CHL1 (By similarity).


亚细胞位置:
Cell membrane Single-pass type I membrane protein Golgi apparatus Trans-Golgi network Endoplasmic reticulum Endosome Cell surface Cytoplasmic vesicle membrane Single-pass type I membrane protein Membrane raft Lysosome Late endosome Early endosome Recycling endosome Cell projection Axon Cell projection Dendrite Predominantly localized to the later Golgi/trans-Golgi network (TGN) and minimally detectable in the early Golgi compartments. A small portion is also found in the endoplasmic reticulum, endosomes and on the cell surface (PubMed:17425515, PubMed:11466313). Colocalization with APP in early endosomes is due to addition of bisecting N-acetylglucosamine wich blocks targeting to late endosomes and lysosomes (By similarity). Retrogradly transported from endosomal compartments to the trans-Golgi network in a phosphorylation- and GGA1- dependent manner (PubMed:15886016).



[1].
"Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE."

[2].
"Two endoplasmic reticulum (ER)/ER Golgi intermediate compartment-based lysine acetyltransferases post-translationally regulate BACE1 levels."

[3].
"A reversible form of lysine acetylation in the ER and Golgi lumen controls the molecular stabilization of BACE1."

[4].
"Reticulons RTN3 and RTN4-B/C interact with BACE1 and inhibit its ability to produce amyloid beta-protein."

[5].
"Mapping of interaction domains mediating binding between BACE1 and RTN/Nogo proteins."
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