EIAab
首页  >  重组蛋白  >  Human MAP1LC3B Recombinant Protein
MAP1LC3B (基因名), Microtubule-associated proteins 1A/1B light chain 3B (蛋白名), MLP3B_HUMAN.
产品名称:

Human MAP1LC3B/ Microtubule-associated proteins 1A/1B light chain 3B Recombinant Protein
微管关联蛋白1轻链3β

货号:

R2880h

商标:
EIAab®
监管等级:
别名:

Autophagy-related protein LC3 B, Autophagy-related ubiquitin-like modifier LC3 B, MAP1 light chain 3-like protein 2, MAP1A/MAP1B light chain 3 B, Microtubule-associated protein 1 light chain 3 beta, MAP1A/MAP1B LC3 B, MAP1ALC3

序列号:
Q9GZQ8
来源:
E.coli
种属:
Human
标签:
His
序列:
1-125aa
预估分子量:
13.75 kDa (monomer)
纯度:
Greater than 95% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Cancer
  • Human MAP1LC3B Protein
  • Human MAP1LC3B Protein
  • Human MAP1LC3B Protein
规格 & 价格: cart
×
Human MAP1LC3B Protein
邮箱 *
消息 *
Please 登录.
产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
Human MAP1LC3B Protein
The PCR product of human MAP1LC3B gene was determined by 1% Agarose stained with EB.
Human MAP1LC3B Protein
Recombinant human MAP1LC3B protein was determined by 12% SDS-PAGE stained with Coomassie Blue under reducing conditions.
基因位点
Cytogenetic band: 16q24.2 by HGNC 16q24.2 by Entrez Gene 16q24.2 by Ensembl
MAP1LC3B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins (By similarity). Interacts at microtubules with CABP1 (via EF-hands 1 and 2) but not with calmodulin (PubMed:15095872). Interacts with FYCO1 (via C-terminus) (PubMed:20100911, PubMed:24089205). Interacts with TP53INP1 and TP53INP2 (PubMed:22470510). Interacts with TBC1D25 (PubMed:21383079). Directly interacts with SQSTM1; this interaction leads to MAP1LC3B recruitment to inclusion bodies containing polyubiquitinated protein aggregates and to inclusion body degradation by autophagy (PubMed:17580304, PubMed:24089205, PubMed:18524774). Interacts with ATG4B, MAPK15 and BNIP3 (PubMed:22948227, PubMed:23209295). Interacts with MAPB1, KEAP1, PCM1, OFD1, CEP131, and TECPR2 (PubMed:20562859, PubMed:24089205). Interacts with TBC1D5 (PubMed:22354992). Found in a complex with UBQLN1 and UBQLN2 (PubMed:20529957). Interacts with UBQLN4 (via STI1 1 and 2 domains). Interacts with UBQLN1 in the presence of UBQLN4 (PubMed:23459205). Interacts with ATG13 (PubMed:24290141). Interacts with FAM134A, FAM134B and FAM134C (PubMed:26040720).


功能:
Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway.


亚细胞位置:
Cytoplasm Cytoskeleton Endomembrane system Lipid-anchor Cytoplasmic vesicle Autophagosome membrane Lipid-anchor Cytoplasmic vesicle Autophagosome LC3-II binds to the autophagic membranes. Localizes also to discrete punctae along the ciliary axoneme (By similarity).


该产品尚未在任何出版物中被引用。

[1].
"Human light chain 3/MAP1LC3B is cleaved at its carboxyl-terminal Met121 to expose Gly120 for lipidation and targeting to autophagosomal membranes."

[2].
"Regulation of endoplasmic reticulum turnover by selective autophagy."

[3].
"Structural basis of the autophagy-related LC3/Atg13 LIR complex: recognition and interaction mechanism."

[4].
"Structural determinants in GABARAP required for the selective binding and recruitment of ALFY to LC3B-positive structures."

[5].
"Modulation of serines 17 and 24 in the LC3-interacting region of Bnip3 determines pro-survival mitophagy versus apoptosis."

[6].
"Ubiquilin4 is an adaptor protein that recruits Ubiquilin1 to the autophagy machinery."

[7].
"Autophagy promotes primary ciliogenesis by removing OFD1 from centriolar satellites."

[8].
"Arginine68 is an essential residue for the C-terminal cleavage of human Atg8 family proteins."

[9].
"Rab GTPase-activating proteins in autophagy: regulation of endocytic and autophagy pathways by direct binding to human ATG8 modifiers."

[10].
"DOR/Tp53inp2 and Tp53inp1 constitute a metazoan gene family encoding dual regulators of autophagy and transcription."
关闭
Sample Data
关闭
Sample Data
关闭
Sample Data
用户中心 close
购物车 close
我的收藏 close
我的足迹 close
清除
产品对比 close
用户中心
购物车
我的收藏
我的足迹
产品对比
回到顶部
通知
new 咨询
规格 数量 单价 (¥) 小计 1 (¥)
小计 2:
triangle
规格 数量 单价 (¥)
你想做我们的代理并得到更低的折扣吗?
请联系我们:
电话:027-59234612(+86)
传真:027-59234610(+86)
邮箱:sales@eiaab.com