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MAP1LC3B (基因名), Microtubule-associated proteins 1A/1B light chain 3B (蛋白名), MLP3B_HUMAN.
产品名称:

Human MAP1LC3B/ Microtubule-associated proteins 1A/1B light chain 3B Recombinant Protein
微管关联蛋白1轻链3β

货号:

R2880h

商标:
EIAab®
监管等级:
别名:

Autophagy-related protein LC3 B, Autophagy-related ubiquitin-like modifier LC3 B, MAP1 light chain 3-like protein 2, MAP1A/MAP1B light chain 3 B, Microtubule-associated protein 1 light chain 3 beta, MAP1A/MAP1B LC3 B, MAP1ALC3

序列号:
Q9GZQ8
来源:
E.coli
种属:
Human
标签:
His
序列:
1-125aa
预估分子量:
13.75 kDa (monomer)
纯度:
Greater than 95% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Cancer
  • Human MAP1LC3B Protein
  • Human MAP1LC3B Protein
  • Human MAP1LC3B Protein
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Human MAP1LC3B Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS


R&D 技术数据
Human MAP1LC3B Protein
The PCR product of human MAP1LC3B gene was determined by 1% Agarose stained with EB.
Human MAP1LC3B Protein
Recombinant human MAP1LC3B protein was determined by 12% SDS-PAGE stained with Coomassie Blue under reducing conditions.
基因位点
Cytogenetic band: 16q24.2 by HGNC 16q24.2 by Entrez Gene 16q24.2 by Ensembl
MAP1LC3B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins (By similarity). Interacts at microtubules with CABP1 (via EF-hands 1 and 2) but not with calmodulin (PubMed:15095872). Interacts with FYCO1 (via C-terminus) (PubMed:20100911, PubMed:24089205). Interacts with TP53INP1 and TP53INP2 (PubMed:22470510). Interacts with TBC1D25 (PubMed:21383079). Directly interacts with SQSTM1; this interaction leads to MAP1LC3B recruitment to inclusion bodies containing polyubiquitinated protein aggregates and to inclusion body degradation by autophagy (PubMed:17580304, PubMed:24089205, PubMed:18524774). Interacts with ATG4B, MAPK15 and BNIP3 (PubMed:22948227, PubMed:23209295). Interacts with MAPB1, KEAP1, PCM1, OFD1, CEP131, and TECPR2 (PubMed:20562859, PubMed:24089205). Interacts with TBC1D5 (PubMed:22354992). Found in a complex with UBQLN1 and UBQLN2 (PubMed:20529957). Interacts with UBQLN4 (via STI1 1 and 2 domains). Interacts with UBQLN1 in the presence of UBQLN4 (PubMed:23459205). Interacts with ATG13 (PubMed:24290141). Interacts with FAM134A, FAM134B and FAM134C (PubMed:26040720).


功能:
Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway.


亚细胞位置:
Cytoplasm Cytoskeleton Endomembrane system Lipid-anchor Cytoplasmic vesicle Autophagosome membrane Lipid-anchor Cytoplasmic vesicle Autophagosome LC3-II binds to the autophagic membranes. Localizes also to discrete punctae along the ciliary axoneme (By similarity).


该产品尚未在任何出版物中被引用。

[1].
"Human light chain 3/MAP1LC3B is cleaved at its carboxyl-terminal Met121 to expose Gly120 for lipidation and targeting to autophagosomal membranes."

[2].
"Regulation of endoplasmic reticulum turnover by selective autophagy."

[3].
"Structural basis of the autophagy-related LC3/Atg13 LIR complex: recognition and interaction mechanism."

[4].
"Structural determinants in GABARAP required for the selective binding and recruitment of ALFY to LC3B-positive structures."

[5].
"Modulation of serines 17 and 24 in the LC3-interacting region of Bnip3 determines pro-survival mitophagy versus apoptosis."

[6].
"Ubiquilin4 is an adaptor protein that recruits Ubiquilin1 to the autophagy machinery."

[7].
"Autophagy promotes primary ciliogenesis by removing OFD1 from centriolar satellites."

[8].
"Arginine68 is an essential residue for the C-terminal cleavage of human Atg8 family proteins."

[9].
"Rab GTPase-activating proteins in autophagy: regulation of endocytic and autophagy pathways by direct binding to human ATG8 modifiers."

[10].
"DOR/Tp53inp2 and Tp53inp1 constitute a metazoan gene family encoding dual regulators of autophagy and transcription."
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