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首页  >  重组蛋白  >  Human ACER1 Recombinant Protein
ACER1 (基因名), Alkaline ceramidase 1 (蛋白名), ACER1_HUMAN.
产品名称:

Human ACER1/ Alkaline ceramidase 1 Recombinant Protein

货号:
-
商标:
EIAab®
监管等级:
别名:

Acylsphingosine deacylase 3, N-acylsphingosine amidohydrolase 3, AlkCDase 1, ASAH3

序列号:
Q8TDN7
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human ACER1 Protein
×
Human ACER1 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS


基因位点
Cytogenetic band: 19p13.3 by HGNC 19p13.3 by Entrez Gene 19p13.3 by Ensembl
ACER1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
N/A


功能:
Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 8.0. Has a highly restricted substrate specificity for the natural stereoisomer of ceramide with D-erythro-sphingosine but not D-ribo-phytosphingosine or D-erythro-dihydrosphingosine as a backbone. May have a role in regulating the levels of bioactive lipids ceramide and sphingosine 1-phosphate, as well as complex sphingolipids.


亚细胞位置:
Endoplasmic reticulum membrane Multi-pass membrane protein


该产品尚未在任何出版物中被引用。

[1].
"Cloning and characterization of a mouse endoplasmic reticulum alkaline ceramidase: an enzyme that preferentially regulates metabolism of very long chain ceramides."

[2].
"Differentiation-associated expression of ceramidase isoforms in cultured keratinocytes and epidermis."

[3].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."

[4].
"Alkaline ceramidase 2 (ACER2) and its product dihydrosphingosine mediate the cytotoxicity of N-(4-hydroxyphenyl)retinamide in tumor cells."

[5].
"Upregulation of the human alkaline ceramidase 1 and acid ceramidase mediates calcium-induced differentiation of epidermal keratinocytes."

[6].
"Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate."

[7].
"Large-scale identification of human genes implicated in epidermal barrier function."

[8].
"[Molecular evolution of neutral ceramidase: signalling molecule and virulence factor]."

[9].
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences."
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