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PTEN (基因名), Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (蛋白名), pten_human.

产品名称:

PTEN Antibody

货号:

P14875Rb

商标:

EIAab^®

监管等级:

RUO

别名:

Mutated in multiple advanced cancers 1, Phosphatase and tensin homolog, MMAC1, TEP1

序列号:

P60484

反应性:

human, mouse

免疫原:

Recombinant human PTEN Protein (R14875h)

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

Cancer

规格 & 价格:

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Human PTEN Polyclonal Antibody

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产品说明书

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R&D 技术数据

PTEN antibody detects PTEN protein at cytosol and nucleus on mouse middle brain by immunohistochemical analysis. Sample: Paraffin-embedded mouse middle brain. PTEN antibody dilution: 1:200.

通用注释

亚单元:

Monomer. The unphosphorylated form interacts with the second PDZ domain of AIP1 and with DLG1 and MAST2 in vitro (PubMed:10646847, PubMed:10760291, PubMed:11707428). Interacts with MAGI2, MAGI3, MAST1 and MAST3, but neither with MAST4 nor with DLG5; interaction with MAGI2 increases protein stability (PubMed:10748157, PubMed:15951562). Interacts with NEDD4 (PubMed:17218260). Interacts with NDFIP1 and NDFIP2; in the presence of NEDD4 or ITCH, this interaction promotes PTEN ubiquitination (PubMed:25801959, PubMed:20534535). Interacts (via C2 domain) with FRK (PubMed:19345329). Interacts with USP7; the interaction is direct (PubMed:18716620). Interacts with ROCK1 (By similarity). Interacts with XIAP/BIRC4 (PubMed:19473982). Interacts with STK11; the interaction phosphorylates PTEN (PubMed:15987703).

功能:

Isoform alpha: Functional kinase, like isoform 1 it antagonizes the PI3K-AKT/PKB signaling pathway. Plays a role in mitochondrial energetic metabolism by promoting COX activity and ATP production, via collaboration with isoform 1 in increasing protein levels of PINK1.

亚细胞位置:

Isoform alpha Secreted May be secreted via a classical signal peptide and reenter into cells with the help of a poly-Arg motif.

数据库链接

UniGene:

Hs.500466

SMR:

P60484

STRING:

9606.ENSP00000361021

KEGG:

hsa:5728

MIM: