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MSH2 (基因名), DNA mismatch repair protein Msh2 (蛋白名), msh2_human.

产品名称:

MSH2 Antibody

货号:

P8706Rb

商标:

EIAab^®

监管等级:

RUO

别名:

MutS protein homolog 2, hMSH2

序列号:

P43246

反应性:

human,mouse,rat

免疫原:

corresponding to a sequence mapping at the 321-574aa of P43246

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

Cancer

规格 & 价格:

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Human MSH2 Polyclonal Antibody

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产品说明书

数据表:

MSDS:

在线询价

数据
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R&D 技术数据

293T lysate was subjected to SDS-Page followed by Western Blot with MSH2 antibody at dillution of 1:500 (Observed molecular weight is about 104kDa)

Immunohistochemistry of paraffin-embedded human kidney cancer tissue using MSH2 antibody.

通用注释

亚单元:

Heterodimer consisting of MSH2-MSH6 (MutS alpha) or MSH2-MSH3 (MutS beta). Both heterodimer form a ternary complex with MutL alpha (MLH1-PMS1). Interacts with EXO1. Part of the BRCA1-associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the RAD50-MRE11-NBS1 protein complex. This association could be a dynamic process changing throughout the cell cycle and within subnuclear domains. Interacts with ATR. Interacts with SLX4/BTBD12; this interaction is direct and links MutS beta to SLX4, a subunit of different structure-specific endonucleases. Interacts with SMARCAD1.

功能:

Component of the post-replicative DNA mismatch repair system (MMR). Forms two different heterodimers: MutS alpha (MSH2-MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. When bound, heterodimers bend the DNA helix and shields approximately 20 base pairs. MutS alpha recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. MutS beta recognizes larger insertion-deletion loops up to 13 nucleotides long. After mismatch binding, MutS alpha or beta forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. In melanocytes may modulate both UV-B-induced cell cycle regulation and apoptosis.

亚细胞位置:

Nucleus

数据库链接

UniGene:

Hs.597656

SMR:

P43246

STRING:

9606.ENSP00000233146

KEGG:

hsa:4436

MIM: