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ABCB4 (基因名), Phosphatidylcholine translocator ABCB4 (蛋白名), mdr3_human.
产品名称:

ABCB4 Antibody

货号:

P10409Rb-h

商标:
EIAab®
监管等级:
别名:

ATP-binding cassette sub-family B member 4, Multidrug resistance protein 3, P-glycoprotein 3, MDR3, PGY3

序列号:
P21439
反应性:
human
免疫原:
corresponding to a sequence mapping at the Recombinant protein of P21439
形态:
Liquid
存储说明:
4℃ for frequent use, -20℃ to -70℃ for 6 months
缓冲液:
0.1M×PBS,50% glycerol,pH7.5
浓度:
200ug/ml
纯化方式:
Immunogen affinity purified
克隆性:
Polyclonal
亚型:
Rabbit IgG
应用:
推荐产品:
研究领域:
Cardiovascular
  • Human ABCB4 Polyclonal Antibody
  • Human ABCB4 Polyclonal Antibody
  • Human ABCB4 Polyclonal Antibody
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Human ABCB4 Polyclonal Antibody
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产品说明书
数据表: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
Human ABCB4 Polyclonal Antibody
Mouse heart tissue lysate was subjected to SDS-PAGE followed by Western Blot with Phosphatidylcholine translocator ABCB4antibody at dilution of 1:300
Immunohistochemical staining of human liver using ABCB4 antibody shows strong positivity in bile canaliculi.
通用注释


亚单元:
May interact with RACK1 (PubMed:19674157). Interacts with HAX1.


功能:
Energy-dependent phospholipid efflux translocator that acts as a positive regulator of biliary lipid secretion. Functions as a floppase that translocates specifically phosphatidylcholine (PC) from the inner to the outer leaflet of the canalicular membrane bilayer into the canaliculi of hepatocytes. Translocation of PC makes the biliary phospholipids available for extraction into the canaliculi lumen by bile salt mixed micelles and therefore protects the biliary tree from the detergent activity of bile salts (PubMed:7957936, PubMed:8898203, PubMed:9366571, PubMed:17523162, PubMed:23468132, PubMed:24806754, PubMed:24723470, PubMed:24594635, PubMed:21820390). Plays a role in the recruitment of phosphatidylcholine (PC), phosphatidylethanolamine (PE) and sphingomyelin (SM) molecules to nonraft membranes and to fu rther enrichment of SM and cholesterol in raft membranes in hepatocytes (PubMed:23468132). Required for proper phospholipid bile formation (By similarity). Indirectly involved in cholesterol efflux activity from hepatocytes into the canalicular lumen in the presence of bile salts in an ATP-dependent manner (PubMed:24045840). May promote biliary phospholipid secretion as canaliculi-containing vesicles from the canalicular plasma membrane (PubMed:9366571). In cooperation with ATP8B1, functions to protect hepatocytes from the deleterious detergent activity of bile salts (PubMed:21820390). Does not confer multidrug resistance.


亚细胞位置:
Cell membrane Multi-pass membrane protein Apical cell membrane Multi-pass membrane protein Membrane raft Cytoplasm Cytoplasmic vesicle Clathrin-coated vesicle Localized at the apical canalicular membrane of the epithelial cells lining the lumen of the bile canaliculi and biliary ductules (By similarity). Transported from the Golgi to the apical bile canalicular membrane in a RACK1-dependent manner (PubMed:19674157). Redistributed into pseudocanaliculi formed between cells in a bezafibrate- or PPARA-dependent manner (PubMed:15258199). Localized preferentially in lipid nonraft domains of canalicular plasma membranes (PubMed:23468132).


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