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ARHGEF1 (基因名), Rho guanine nucleotide exchange factor 1 (蛋白名), arhg1_human.
产品名称:

ARHGEF1 Antibody

货号:

P1577Rb

商标:
EIAab®
监管等级:
别名:

115 kDa guanine nucleotide exchange factor, Sub1.5, p115-RhoGEF

序列号:
Q92888
反应性:
human, mouse
免疫原:
Recombinant human ARHGEF1 protein ( R1577h )
形态:
Liquid
存储说明:
4℃ for frequent use, -20℃ to -70℃ for 6 months
缓冲液:
0.1M×PBS,50% glycerol,pH7.5
浓度:
200ug/ml
纯化方式:
Immunogen affinity purified
克隆性:
Polyclonal
亚型:
Rabbit IgG
应用:
推荐产品:
研究领域:
Epigenetics
  • Human ARHGEF1 Polyclonal Antibody
  • Human ARHGEF1 Polyclonal Antibody
  • Human ARHGEF1 Polyclonal Antibody
规格 & 价格: cart
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Human ARHGEF1 Polyclonal Antibody
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产品说明书
数据表: 下载说明书
MSDS: MSDS
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R&D 技术数据
Human ARHGEF1 Polyclonal Antibody
ARHGEF1 monoclonal antibody. Western Blot analysis of ARHGEF1 expression in K-562.
Immunohistochemical staining of human lymph node shows strong cytoplasmic positivity.
通用注释


亚单元:
Interacts with RHOA, GNA12 and GNA13. Homooligomerizes through the coiled coil region. May interact with CCPG1 (By similarity). Interacts with CTNNAL1.


功能:
Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation.


亚细胞位置:
Cytoplasm Membrane Translocated to the membrane by activated GNA13 or LPA stimulation.


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