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AGRN (基因名), Agrin (蛋白名), agrin_human.
产品名称:

AGRN Antibody

货号:

P1303Rb-h

商标:
EIAab®
监管等级:
别名:

AGRIN

序列号:
O00468
反应性:
human
免疫原:
corresponding to a sequence mapping at the 311-459aa of O00468
形态:
Liquid
存储说明:
4℃ for frequent use, -20℃ to -70℃ for 6 months
缓冲液:
0.1M×PBS,50% glycerol,pH7.5
浓度:
200ug/ml
纯化方式:
Immunogen affinity purified
克隆性:
Polyclonal
亚型:
Rabbit IgG
应用:
推荐产品:
研究领域:
Neurosciences
  • Human AGRN Polyclonal Antibody
  • Human AGRN Polyclonal Antibody
  • Human AGRN Polyclonal Antibody
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Human AGRN Polyclonal Antibody
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产品说明书
数据表: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
Human AGRN Polyclonal Antibody
HEK293T whole cell was subjected to SDS-PAGE followed by Western Blot with Agrinantibody at dilution of 1:300
Agrin in Mouse Kidney. Agrin was detected in perfusion fixed frozen sections of mouse kidney using Goat Anti-Rat Agrin Antigen Affinity-purified Polyclonal Antibody at 0.1 μg/mL overnight at 4 °C.
通用注释


亚单元:
Monomer (By similarity). Interacts (N-terminal subunit) with TGF-beta family members, BMP2 AND BMP4; the interactions inhibit the activity of these growth factors. Interacts with TGFB1; the interaction enhances the activity of TGFB1 (By similarity). Component of the AGRN-LRP4 complex that consists of a tetramer of two AGRN-LRP4 heterodimers. Interacts (via the laminin G-like 3 domain) directly with LRP4; the interaction is required for activation of MUSK and clustering of AChR and requires the 'z8' insert present in the z(+8) isoforms. Interacts with DAG1; the interaction is influenced by cell surface glycosaminoglycans and by alternative splicing of AGRN.


功能:
Agrin C-terminal 22 kDa fragment: this released fragment is important for agrin signaling and to exert a maximal dendritic filopodia-inducing effect. All 'z' splice variants (z+) of this fragment also show an increase in the number of filopodia.


亚细胞位置:
Isoform 2 Cell junction Synapse Cell membrane Single-pass type II membrane protein


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