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PDK1 (基因名), [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (蛋白名), pdk1_human.
产品名称:

PDK1 Antibody
丙酮酸脱氢酶[硫辛酰胺]激酶同功酶1

货号:

M10511Rb

商标:
EIAab®
监管等级:
别名:

Pyruvate dehydrogenase kinase isoform 1, PDH kinase 1, PDHK1

反应性:
human,mouse,rat
免疫原:
Recombinant human PDK1 protein ( R10511h )
形态:
Liquid
存储说明:
4℃ for frequent use, -20℃ to -70℃ for 6 months
缓冲液:
0.1M×PBS,50% glycerol,pH7.5
浓度:
200ug/ml
纯化方式:
Immunogen affinity purified
克隆性:
Monoclonal
亚型:
Mouse IgG
应用:
推荐产品:
研究领域:
Cancer
  • Human PDK1 Monoclonal Antibody
  • Human PDK1 Monoclonal Antibody
  • Human PDK1 Monoclonal Antibody
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Human PDK1 Monoclonal Antibody
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通用注释


亚单元:
Homodimer, and heterodimer with PDK2. Interacts with the pyruvate dehydrogenase complex subunit DLAT, and is part of the multimeric pyruvate dehydrogenase complex that contains multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (DLAT, E2) and lipoamide dehydrogenase (DLD, E3).


功能:
Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress.


亚细胞位置:
Mitochondrion matrix


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