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Ilk (基因名), Integrin-linked protein kinase (蛋白名), ilk_mouse.
产品名称:

Mouse Ilk/ Integrin-linked protein kinase ELISA Kit
整合素连接蛋白激酶

货号:

E1587m

商标:
EIAab®
监管等级:
检测方法:
ELISA
实验类型:
Sandwich
检测范围:
0.625-40ng/mL
灵敏度:
0.312ng/mL
特异性:
Natural and recombinant mouse Integrin-linked protein kinase
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
实验步骤:
实验步骤
研究领域:
Cancer
Mouse Ilk ELISA Kit
规格 & 价格: cart
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Mouse Ilk ELISA Kit
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


通用注释


亚单元:
Interacts with FERMT2 (PubMed:18483218). Interacts with the cytoplasmic domain of ITGB1 (By similarity). Could also interact with integrin ITGB2, ITGB3 and/or ITGB5 (By similarity). Interacts (via ANK repeats) with LIMS1 and LIMS2 (By similarity). Interacts with PARVA and PARVB; these compete for the same binding site (By similarity). Interacts probably also with TGFB1I1 (PubMed:16737959). Interacts (via ANK repeats) with EPHA1 (via SAM domain); stimulated by EFNA1 but independent of the kinase activity of EPHA1 (By similarity). Interacts with LIMD2; leading to activate the protein kinase activity.


功能:
Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B.


亚细胞位置:
Cell junction Focal adhesion Cell membrane Peripheral membrane protein Cytoplasmic side Cytoplasm Myofibril Sarcomere Cell projection Lamellipodium


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