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Bnip3 (基因名), BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (蛋白名), bnip3_mouse.
产品名称:

Mouse Bnip3/ BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 ELISA Kit
BCL2/腺病毒E1B19kDa蛋白相互作用蛋白3

货号:

E15232m

商标:
EIAab®
监管等级:
别名:

Nip3

检测方法:
ELISA
实验类型:
Sandwich
检测范围:
78-5000pg/mL
灵敏度:
19pg/mL
特异性:
Natural and recombinant mouse BCL2/adenovirus E1B 19 kDa protein-interacting protein 3
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
实验步骤:
实验步骤
研究领域:
Cancer
Mouse Bnip3 ELISA Kit
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


线性
线性:给定样本通过梯度稀释,每次稀释的测量值与理论值的比值。

Sample

1:2

1:4

1:8

1:16

serum(n=5)

92-101%

105-117%

105-115%

88-98%

EDTA plasma(n=5)

108-108%

91-91%

98-106%

82-92%

heparin plasma(n=5)

113-122%

 

85-93%

87-99%

108-117%

 

通用注释


亚单元:
Homodimer. Binds to BCL2. Interacts with BNIP3L and ACAA2. Interacts (via BH3 domain) with SPATA18 (via coiled-coil domains). Interacts with BOK; promotes BOK oligomerization.


功能:
Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2 (By similarity). Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane may play a critical role in the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix (By similarity). The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix (By similarity). Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway.


亚细胞位置:
Mitochondrion Mitochondrion outer membrane Single-pass membrane protein Coexpression with the EIB 19-kDa protein results in a shift in NIP3 localization pattern to the nuclear envelope. Colocalizes with ACAA2 in the mitochondria. Colocalizes with SPATA18 at the mitochondrion outer membrane (By similarity).


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