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AHR (基因名), Aryl hydrocarbon receptor (蛋白名), ahr_human.
产品名称:

Human AHR/ Aryl hydrocarbon receptor ELISA Kit
芳烃受体

货号:

E1354h

商标:
EIAab®
监管等级:
别名:

Class E basic helix-loop-helix protein 76, bHLHe76, Ah receptor, BHLHE76

检测方法:
ELISA
实验类型:
Sandwich
检测范围:
0.312-20ng/mL
灵敏度:
0.15ng/mL
特异性:
Natural and recombinant human Aryl hydrocarbon receptor
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
实验步骤:
实验步骤
研究领域:
Cancer
Human AHR ELISA Kit
规格 & 价格: cart
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Human AHR ELISA Kit
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产品说明书
数据表: 下载说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


精密度
批内差:已知浓度的3个样本在一个板子内重复检测20次,以评估批内精密度。
批内 CV: ≤4.9%
批间差:已知浓度的3个样本在不同的板子上重复测定5次,以评估测定批间精密度。
批间 CV: ≤7.9%
回收率
回收率:低、中和高浓度的分析物被掺入到血清或者血浆样本中,进行回收实验测定。

Sample Type

Average(%)

Recovery Range(%)

Serum

88

82-94

Plasma

90

84-96

 

 

 

 

线性
线性:给定样本通过梯度稀释,每次稀释的测量值与理论值的比值。

Sample

1:2

1:4

1:8

1:16

serum(n=5)

86-96%

83-92%

91-101%

103-114%

EDTA plasma(n=5)

105-116%

111-121%

103-112%

112-122%

heparin plasma(n=5)

91-91%

 

94-107%

106-115%

105-117%

 

通用注释


亚单元:
Binds MYBBP1A (By similarity). Efficient DNA binding requires dimerization with another bHLH protein. In the nucleus, heterodimer of AHR and ARNT. Interacts with coactivators including SRC-1, RIP140 and NOCA7, and with the corepressor SMRT. Interacts with NEDD8 and IVNS1ABP. Interacts with ARNTL/BMAL1. Interacts with HSP90AB1.


功能:
Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues. Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1. Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1.


亚细胞位置:
Cytoplasm Nucleus Initially cytoplasmic; upon binding with ligand and interaction with a HSP90, it translocates to the nucleus.


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