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Mmp24 (基因名), Matrix metalloproteinase-24 (蛋白名), MMP24_MOUSE.
产品名称:

Mouse Mmp24/ Matrix metalloproteinase-24 ELISA Kit
矩阵metalloproteinase-24

货号:

E0555m

商标:
EIAab®
监管等级:
别名:

Matrix metalloproteinase-21, Membrane-type matrix metalloproteinase 5, Membrane-type-5 matrix metalloproteinase, MMP-21, MT-MMP 5, MT5-MMP, MMP-24, Mmp21, Mt5mmp

检测方法:
ELISA
实验类型:
Sandwich
检测范围:
31.2-2000pg/ml
灵敏度:
15.71pg/mL
特异性:
Natural and recombinant mouse Matrix metalloproteinase-24
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
实验步骤:
实验步骤
研究领域:
-
Mouse Mmp24 ELISA Kit
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Mouse Mmp24 ELISA Kit
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


精密度
批内差:已知浓度的3个样本在一个板子内重复检测20次,以评估批内精密度。
批内 CV: ≤6.9%
批间差:已知浓度的3个样本在不同的板子上重复测定5次,以评估测定批间精密度。
批间 CV: ≤8.7%
回收率
回收率:低、中和高浓度的分析物被掺入到血清或者血浆样本中,进行回收实验测定。

Sample Type

Average(%)

Recovery Range(%)

Serum

87

81-93

Plasma

89

83-95

 

 

 

 

线性
线性:给定样本通过梯度稀释,每次稀释的测量值与理论值的比值。

Sample

1:2

1:4

1:8

1:16

serum(n=5)

115-127%

97-107%

80-90%

91-102%

EDTA plasma(n=5)

83-93%

93-103%

101-110%

111-121%

heparin plasma(n=5)

93-102%

 

86-95%

92-102%

115-127%

 

通用注释


亚单元:
Interacts with GRIP1 and GRIP2 (By similarity). Interacts (via PDZ-binding motif) with APBA3 (via PDZ domain).


功能:
Metalloprotease that mediates cleavage of N-cadherin (CDH2) and acts as a regulator of neuro-immune interactions and neural stem cell quiescence (PubMed:19805319, PubMed:24952463). Involved in cell-cell interactions between nociceptive neurites and mast cells, possibly by mediating cleavage of CDH2, thereby acting as a mediator of peripheral thermal nociception and inflammatory hyperalgesia (PubMed:19805319). Key regulator of neural stem cells quiescence by mediating cleavage of CDH2, affecting CDH2-mediated anchorage of neural stem cells to ependymocytes in the adult subependymal zone, leading to modulate their quiescence (PubMed:24952463). May play a role in axonal growth (PubMed:11714638). Able to activate progelatinase A. May also be a proteoglycanase involved in degradation of proteoglycans, such as dermatan sulfate and chondroitin sulfate proteoglycans. Cleaves partially fibronectin, but not collagen type I, nor laminin (PubMed:10622708).


亚细胞位置:
Processed matrix metalloproteinase-24 Secreted Extracellular space Extracellular matrix Also shed from cell surface as soluble proteinase, by a proteolytic cleavage.


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