Abcb4 (GeneName), Phosphatidylcholine translocator ABCB4 (ProteinName), MDR3_MOUSE.
Mouse Abcb4/ Phosphatidylcholine translocator ABCB4 ELISA Kit
ATP-binding cassette sub-family B member 4, Multidrug resistance protein 2, Multidrug resistance protein 3, P-glycoprotein 2, P-glycoprotein 3, Mdr2, Pgy-2, Pgy2
Natural and recombinant mouse Phosphatidylcholine translocator ABCB4
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
May interact with RACK1. Interacts with HAX1.
Energy-dependent phospholipid efflux translocator that acts as a positive regulator of biliary lipid secretion. Functions as a floppase that translocates specifically phosphatidylcholine (PC) from the inner to the outer leaflet of the canalicular membrane bilayer into the canaliculi between hepatocytes. Translocation of PC makes the biliary phospholipids available for extraction into the canaliculi lumen by bile salt mixed micelles and therefore protects the biliary tree from the detergent activity of bile salts (PubMed:8106172, PubMed:7912658, PubMed:7592705, PubMed:7814632, PubMed:8725158, PubMed:9366571). Plays a role in the recruitment of phosphatidylcholine (PC), phosphatidylethanolamine (PE) and sphingomyelin (SM) molecules to nonraft membranes and to further enrichment of SM and cholesterol in raft membranes in hepatocytes (By similarity). Required for proper phospholipid bile formation (PubMed:8106172). Indirectly involved in cholesterol efflux activity from hepatocytes into the canalicular lumen in the presence of bile salts in an ATP-dependent manner (PubMed:7814632, PubMed:8725158). May promote biliary phospholipid secretion as canaliculi-containing vesicles from the canalicular plasma membrane (PubMed:9366571). In cooperation with ATP8B1, functions to protect hepatocytes from the deleterious detergent activity of bile salts (PubMed:21820390). Does not confer multidrug resistance (PubMed:1990275).
Cell membrane Multi-pass membrane protein Apical cell membrane Multi-pass membrane protein Membrane raft Cytoplasm Cytoplasmic vesicle Clathrin-coated vesicle Transported from the Golgi to the apical bile canalicular membrane in a RACK1-dependent manner. Redistributed into pseudocanaliculi formed between cells in a bezafibrate- or PPARA-dependent manner (By similarity). Localized at the apical canalicular membrane of the epithelial cells lining the lumen of the bile canaliculi and biliary ductules (PubMed:1381362, PubMed:8106172, PubMed:8615769). Localized preferentially in lipid nonraft domains of canalicular plasma membranes (PubMed:23468132).
MDLEAARNGT | ARRLDGDFEL | GSISNQGREK | KKKVNLIGLL | TLFRYSDWQD |
KLFMFLGTLM | AIAHGSGLPL | MMIVFGEMTD | KFVDNTGNFS | LPVNFSLSML |
NPGRILEEEM | TRYAYYYSGL | GGGVLVAAYI | QVSFWTLAAG | RQIKKIRQKF |
FHAILRQEMG | WFDIKGTTEL | NTRLTDDVSK | ISEGIGDKVG | MFFQAIATFF |
AGFIVGFIRG | WKLTLVIMAI | SPILGLSTAV | WAKILSTFSD | KELAAYAKAG |
AVAEEALGAI | RTVIAFGGQN | KELERYQKHL | ENAKKIGIKK | AISANISMGI |
AFLLIYASYA | LAFWYGSTLV | ISKEYTIGNA | MTVFFSILIG | AFSVGQAAPC |
IDAFANARGA | AYVIFDIIDN | NPKIDSFSER | GHKPDNIKGN | LEFSDVHFSY |
PSRANIKILK | GLNLKVKSGQ | TVALVGNSGC | GKSTTVQLLQ | RLYDPTEGKI |
SIDGQDIRNF | NVRCLREIIG | VVSQEPVLFS | TTIAENIRYG | RGNVTMDEIE |
KAVKEANAYD | FIMKLPQKFD | TLVGDRGAQL | SGGQKQRIAI | ARALVRNPKI |
LLLDEATSAL | DTESEAEVQA | ALDKAREGRT | TIVIAHRLST | IRNADVIAGF |
EDGVIVEQGS | HSELMKKEGI | YFRLVNMQTA | GSQILSEEFE | VELSDEKAAG |
DVAPNGWKAR | IFRNSTKKSL | KSPHQNRLDE | ETNELDANVP | PVSFLKVLKL |
NKTEWPYFVV | GTVCAIANGA | LQPAFSIILS | EMIAIFGPGD | DAVKQQKCNM |
FSLVFLGLGV | LSFFTFFLQG | FTFGKAGEIL | TTRLRSMAFK | AMLRQDMSWF |
DDHKNSTGAL | STRLATDAAQ | VQGATGTRLA | LIAQNTANLG | TGIIISFIYG |
WQLTLLLLSV | VPFIAVAGIV | EMKMLAGNAK | RDKKEMEAAG | KIATEAIENI |
RTVVSLTQER | KFESMYVEKL | HGPYRNSVRK | AHIYGITFSI | SQAFMYFSYA |
GCFRFGSYLI | VNGHMRFKDV | ILVFSAIVLG | AVALGHASSF | APDYAKAKLS |
AAYLFSLFER | QPLIDSYSGE | GLWPDKFEGS | VTFNEVVFNY | PTRANVPVLQ |
GLSLEVKKGQ | TLALVGSSGC | GKSTVVQLLE | RFYDPMAGSV | LLDGQEAKKL |
NVQWLRAQLG | IVSQEPILFD | CSIAENIAYG | DNSRVVPHDE | IVRAAKEANI |
HPFIETLPQK | YNTRVGDKGT | QLSGGQKQRI | AIARALIRQP | RVLLLDEATS |
ALDTESEKVV | QEALDKAREG | RTCIVIAHRL | STIQNADLIV | VIENGKVKEH |
GTHQQLLAQK | GIYFSMVNIQ | AGTQNL
This product has not yet been referenced specifically in any publications.
"A new splicing site mutation of the ABCB4 gene in intrahepatic cholestasis of pregnancy with raised serum gamma-GT."
"Mutations and polymorphisms in the bile salt export pump and the multidrug resistance protein 3 associated with drug-induced liver injury."
"Genetic variability, haplotype structures, and ethnic diversity of hepatic transporters MDR3 (ABCB4) and bile salt export pump (ABCB11)."
"Sequence analysis of bile salt export pump (ABCB11) and multidrug resistance p-glycoprotein 3 (ABCB4, MDR3) in patients with intrahepatic cholestasis of pregnancy."
"MDR3 gene defect in adults with symptomatic intrahepatic and gallbladder cholesterol cholelithiasis."
"Common variants of ABCB4 and ABCB11 and plasma lipid levels: a study in sib pairs with gallstones, and controls."
"Receptor for activated C-kinase 1 regulates the cellular localization and function of ABCB4."
"ABCB4 gene mutations and single-nucleotide polymorphisms in women with intrahepatic cholestasis of pregnancy."
"ABCB4 sequence variations in young adults with cholesterol gallstone disease."
"ABCB4 heterozygous gene mutations associated with fibrosing cholestatic liver disease in adults."
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