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首页  >  酶联免疫试剂盒  >  Mouse Abcb4 ELISA Kit
Abcb4 (基因名), Phosphatidylcholine translocator ABCB4 (蛋白名), MDR3_MOUSE.
产品名称:

Mouse Abcb4/ Phosphatidylcholine translocator ABCB4 ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

ATP-binding cassette sub-family B member 4, Multidrug resistance protein 2, Multidrug resistance protein 3, P-glycoprotein 2, P-glycoprotein 3, Mdr2, Pgy-2, Pgy2

检测方法:
ELISA
特异性:
Natural and recombinant mouse Phosphatidylcholine translocator ABCB4
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
Cardiovascular
Mouse Abcb4 ELISA Kit
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Mouse Abcb4 ELISA Kit
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产品说明书


通用注释


亚单元:
May interact with RACK1. Interacts with HAX1.


功能:
Energy-dependent phospholipid efflux translocator that acts as a positive regulator of biliary lipid secretion. Functions as a floppase that translocates specifically phosphatidylcholine (PC) from the inner to the outer leaflet of the canalicular membrane bilayer into the canaliculi between hepatocytes. Translocation of PC makes the biliary phospholipids available for extraction into the canaliculi lumen by bile salt mixed micelles and therefore protects the biliary tree from the detergent activity of bile salts (PubMed:8106172, PubMed:7912658, PubMed:7592705, PubMed:7814632, PubMed:8725158, PubMed:9366571). Plays a role in the recruitment of phosphatidylcholine (PC), phosphatidylethanolamine (PE) and sphingomyelin (SM) molecules to nonraft membranes and to further enrichment of SM and cholesterol in raft membranes in hepatocytes (By similarity). Required for proper phospholipid bile formation (PubMed:8106172). Indirectly involved in cholesterol efflux activity from hepatocytes into the canalicular lumen in the presence of bile salts in an ATP-dependent manner (PubMed:7814632, PubMed:8725158). May promote biliary phospholipid secretion as canaliculi-containing vesicles from the canalicular plasma membrane (PubMed:9366571). In cooperation with ATP8B1, functions to protect hepatocytes from the deleterious detergent activity of bile salts (PubMed:21820390). Does not confer multidrug resistance (PubMed:1990275).


亚细胞位置:
Cell membrane Multi-pass membrane protein Apical cell membrane Multi-pass membrane protein Membrane raft Cytoplasm Cytoplasmic vesicle Clathrin-coated vesicle Transported from the Golgi to the apical bile canalicular membrane in a RACK1-dependent manner. Redistributed into pseudocanaliculi formed between cells in a bezafibrate- or PPARA-dependent manner (By similarity). Localized at the apical canalicular membrane of the epithelial cells lining the lumen of the bile canaliculi and biliary ductules (PubMed:1381362, PubMed:8106172, PubMed:8615769). Localized preferentially in lipid nonraft domains of canalicular plasma membranes (PubMed:23468132).


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