CHRNA2 (GeneName), Neuronal acetylcholine receptor subunit alpha-2 (ProteinName), ACHA2_CHICK.
Product Name:
Chicken CHRNA2/ Neuronal acetylcholine receptor subunit alpha-2 ELISA Kit
Cat.#:
E1926c
Brand:
EIAab®
Regulatory Status:
Detection Method:
ELISA
Specificity:
Natural and recombinant chicken Neuronal acetylcholine receptor subunit alpha-2
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
Neurosciences
- Data
- Citations
- Publication
- Sequence / 3D
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General Annotation
Sub Unit:
Neuronal AChR seems to be composed of two different type of subunits: alpha and non-alpha (also called beta). A functional receptor seems to consist of two alpha-chains and three non-alpha chains.
Function:
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Subcellular Location:
Cell junction
Synapse
Postsynaptic cell membrane
Multi-pass membrane protein
Cell membrane
Multi-pass membrane protein
Valid Sequence:
This product has not yet been referenced specifically in any publications.
[1].
"CHRNA2 mutations are rare in the NFLE population: evaluation of a large cohort of Italian patients."
[2].
"A novel mutation of the nicotinic acetylcholine receptor gene CHRNA4 in sporadic nocturnal frontal lobe epilepsy."
[3].
"Why do young women smoke? V. Role of direct and interactive effects of nicotinic cholinergic receptor gene variation on neurocognitive function."
[4].
"A major role of the nicotinic acetylcholine receptor gene CHRNA2 in autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) is unlikely."
[5].
"Increased sensitivity of the neuronal nicotinic receptor alpha 2 subunit causes familial epilepsy with nocturnal wandering and ictal fear."
[6].
"Crystal structure of a human neuronal nAChR extracellular domain in pentameric assembly: Ligand-bound α2 homopentamer."
[7].
"Mutation of CHRNA2 in a family with benign familial infantile seizures: Potential role of nicotinic acetylcholine receptor in various phenotypes of epilepsy."
[8].
"Human variation in alcohol response is influenced by variation in neuronal signaling genes."
[9].
"Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans."
[10].
"A large-scale candidate gene association study of age at menarche and age at natural menopause."
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