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首页  >  酶联免疫试剂盒  >  Human ACD ELISA Kit
ACD (基因名), Adrenocortical dysplasia protein homolog (蛋白名), ACD_HUMAN.
产品名称:

Human ACD/ Adrenocortical dysplasia protein homolog ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

POT1 and TIN2-interacting protein, PIP1, PTOP, TINT1, TPP1

检测方法:
ELISA
特异性:
Natural and recombinant human Adrenocortical dysplasia protein homolog
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Human ACD ELISA Kit
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产品说明书


通用注释


亚单元:
Component of the shelterin complex (telosome) composed of TERF1, TERF2, TINF2, TERF2IP ACD and POT1. Forms heterodimers with POT1. Identified in a complex with POT1 and single-stranded telomeric DNA. Interacts with STN1 and TINF2.


功能:
Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by recruiting telomerase to telomeres and increasing its processivity. May play a role in organogenesis.


亚细胞位置:
Nucleus Chromosome Telomere


该产品尚未在任何出版物中被引用。

[1].
"PTOP interacts with POT1 and regulates its localization to telomeres."

[2].
"POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex."

[3].
"TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres."

[4].
"Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins."

[5].
"Inherited bone marrow failure associated with germline mutation of ACD, the gene encoding telomere protein TPP1."

[6].
"Genetic variants in eleven telomere-associated genes and the risk of incident cardio/cerebrovascular disease: The Women's Genome Health Study."

[7].
"Polymorphisms in telomere-associated genes, breast cancer susceptibility and prognosis."

[8].
"OB fold-containing protein 1 (OBFC1), a human homolog of yeast Stn1, associates with TPP1 and is implicated in telomere length regulation."

[9].
"The POT1-TPP1 telomere complex is a telomerase processivity factor."

[10].
"Novel polymorphisms and lack of mutations in the ACD gene in patients with ACTH resistance syndromes."
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