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RYR2 (GeneName), Ryanodine receptor 2 (ProteinName), 10709_EIAAB.
Product Name:

Human RYR2/ Ryanodine receptor 2 ELISA Kit



Regulatory Status:

RYR-2,Cardiac muscle ryanodine receptor,Cardiac muscle ryanodine receptor-calcium release channel,Type 2 ryanodine receptor

Detection Method:
Natural and recombinant human Ryanodine receptor 2
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
Product Overview:
E1387-1h is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the A Disintegrin and Metalloprotease 30 (Ryanodine receptor 2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing Ryanodine receptor 2. The ELISA analytical biochemical technique of the E1387-1h kit is based on Ryanodine receptor 2 antibody-Ryanodine receptor 2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect Ryanodine receptor 2 antigen targets in samples. The ELISA Kit is designed to detect native, recombinant, Ryanodine receptor 2. Appropriate sample types may include undiluted human body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
Human RYR2 ELISA Kit
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Human RYR2 ELISA Kit
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Product Datasheets

General Annotation

Sub Unit:
Homotetramer. Can also form heterotetramers with RYR1 and RYR3 (By similarity). Interacts with FKBP1A and FKBP1B; these interactions may stabilize the channel in its closed state and prevent Ca(2+) leaks. Interacts with CALM and S100A1; these interactions regulate channel activity. Identified in a complex composed of RYR2, FKBP1B, PKA catalytic subunit, PRKAR2A, AKAP6, and the protein phosphatases PP2A and PP1. Interacts directly with FKBP1B, PKA, PP1 and PP2A. Interacts with SELENON.

Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development.

Subcellular Location:
Sarcoplasmic reticulum membrane Multi-pass membrane protein Membrane Multi-pass membrane protein Sarcoplasmic reticulum The number of predicted transmembrane domains varies between orthologs, but both N-terminus and C-terminus seem to be cytoplasmic.

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