RYR2 (GeneName), Ryanodine receptor 2 (ProteinName), 10709_EIAAB.
Product Name:
Human RYR2/ Ryanodine receptor 2 ELISA Kit
Cat.#:
E1387-1h
Brand:
EIAab®
Regulatory Status:
Alternative:
RYR-2, Cardiac muscle ryanodine receptor, Cardiac muscle ryanodine receptor-calcium release channel, Type 2 ryanodine receptor
Detection Method:
ELISA
Specificity:
Natural and recombinant human Ryanodine receptor 2
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
-
- Data
- Citations
- Sequence / 3D
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General Annotation
Sub Unit:
Homotetramer. Can also form heterotetramers with RYR1 and RYR3 (By similarity). Interacts with FKBP1A and FKBP1B; these interactions may stabilize the channel in its closed state and prevent Ca(2+) leaks. Interacts with CALM and S100A1; these interactions regulate channel activity. Identified in a complex composed of RYR2, FKBP1B, PKA catalytic subunit, PRKAR2A, AKAP6, and the protein phosphatases PP2A and PP1. Interacts directly with FKBP1B, PKA, PP1 and PP2A. Interacts with SELENON.
Function:
Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development.
Subcellular Location:
Sarcoplasmic reticulum membrane
Multi-pass membrane protein
Membrane
Multi-pass membrane protein
Sarcoplasmic reticulum
The number of predicted transmembrane domains varies between orthologs, but both N-terminus and C-terminus seem to be cytoplasmic.
Database link
Valid Sequence:
This product has not yet been referenced specifically in any publications.
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