PDK1 (基因名), [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (蛋白名), pdk1_human.
产品名称:
Human PDK1/ [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial CLIA Kit
丙酮酸脱氢酶[硫辛酰胺]激酶同功酶1
货号:
U10511h
商标:
EIAab®
监管等级:
别名:
Pyruvate dehydrogenase kinase isoform 1, PDH kinase 1, PDHK1
检测方法:
CLIA
实验类型:
Sandwich
检测范围:
39-2500pg/mL
特异性:
Natural and recombinant human [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
Cancer
通用注释
亚单元:
Homodimer, and heterodimer with PDK2. Interacts with the pyruvate dehydrogenase complex subunit DLAT, and is part of the multimeric pyruvate dehydrogenase complex that contains multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (DLAT, E2) and lipoamide dehydrogenase (DLD, E3).
功能:
Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress.
亚细胞位置:
Mitochondrion matrix
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