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BACE1 (基因名), Beta-secretase 1 (蛋白名), bace1_human.

产品名称:

BACE1 Antibody

货号:

P0718Rb

商标:

EIAab^®

监管等级:

RUO

别名:

Aspartyl protease 2, Beta-site amyloid precursor protein cleaving enzyme 1, Memapsin-2, Membrane-associated aspartic protease 2, ASP2, Beta-site APP cleaving enzyme 1, BACE, KIAA1149

序列号:

P56817

反应性:

human, mouse, zebrafish

免疫原:

Recombinant human BACE1 Protein (R0718h)

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

Neurosciences

规格 & 价格:

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Human BACE1 Polyclonal Antibody

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产品说明书

数据表:

MSDS:

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R&D 技术数据

ACE1 antibody detects BACE1 protein at cytosol and membrane on mouse lung by immunohistochemical analysis. BACE1 antibody dilution: 1:500.

通用注释

亚单元:

Monomer. Interacts (via DXXLL motif) with GGA1, GGA2 and GGA3 (via their VHS domain); the interaction highly increases when BACE1 is phosphorylated at Ser-498 (PubMed:14567678, PubMed:15886016). Interacts with RTN3 and RTN4 (PubMed:15286784, PubMed:16965550, PubMed:16979658). Interacts with SNX6 (PubMed:20354142). Interacts with PCSK9 (PubMed:18660751). Interacts with NAT8 and NAT8B (PubMed:19011241). Interacts with BIN1 (PubMed:27179792). Interacts (via extracellular domain) with ADAM10 (via extracellular domain) (By similarity). Interacts with SORL1; this interaction may affect binding with APP and hence reduce APP cleavage (PubMed:16407538).

功能:

Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase (PubMed:10656250, PubMed:10677483, PubMed:20354142). Cleaves CHL1 (By similarity).

亚细胞位置:

Cell membrane Single-pass type I membrane protein Golgi apparatus Trans-Golgi network Endoplasmic reticulum Endosome Cell surface Cytoplasmic vesicle membrane Single-pass type I membrane protein Membrane raft Lysosome Late endosome Early endosome Recycling endosome Cell projection Axon Cell projection Dendrite Predominantly localized to the later Golgi/trans-Golgi network (TGN) and minimally detectable in the early Golgi compartments. A small portion is also found in the endoplasmic reticulum, endosomes and on the cell surface (PubMed:17425515, PubMed:11466313). Colocalization with APP in early endosomes is due to addition of bisecting N-acetylglucosamine wich blocks targeting to late endosomes and lysosomes (By similarity). Retrogradly transported from endosomal compartments to the trans-Golgi network in a phosphorylation- and GGA1- dependent manner (PubMed:15886016).

数据库链接

UniGene:

Hs.504003

SMR:

P56817

STRING:

9606.ENSP00000318585

KEGG:

hsa:23621

MIM:

604252

Pfam: