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NANOG (基因名), Homeobox protein NANOG (蛋白名), NANOG_BOVIN.
产品名称:

Bovine NANOG/ Homeobox protein NANOG ELISA Kit
同源异形盒蛋白NANOG

货号:

E14436b

商标:
EIAab®
监管等级:
别名:

Homeobox transcription factor Nanog

检测方法:
ELISA
实验类型:
Sandwich
特异性:
Natural and recombinant bovine Homeobox protein NANOG
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
实验步骤:
实验步骤
研究领域:
-
Bovine NANOG ELISA Kit
规格 & 价格: cart
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Bovine NANOG ELISA Kit
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


通用注释


亚单元:
Interacts with SMAD1 and SALL4. Interacts with ZNF281/ZFP281. Interacts with PCGF1.


功能:
Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator and repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3'. Able to autorepress its expression in differentiating (ES) cells: binds to its own promoter following interaction with ZNF281/ZFP281, leading to recruitment of the NuRD complex and subsequent repression of expression. When overexpressed, promotes cells to enter into S phase and proliferation.


亚细胞位置:
Nucleus


该产品尚未在任何出版物中被引用。
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