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MCL1 (基因名), Induced myeloid leukemia cell differentiation protein Mcl-1 (蛋白名), MCL1_HUMAN.
产品名称:

Human MCL1/ Induced myeloid leukemia cell differentiation protein Mcl-1 ELISA Kit
诱导骨髓性白血病细胞分化蛋白MCI-1

货号:

E2097h

商标:
EIAab®
监管等级:
别名:

Bcl-2-like protein 3, Bcl-2-related protein EAT/mcl1, mcl1/EAT, Bcl2-L-3, BCL2L3

检测方法:
ELISA
实验类型:
Sandwich
检测范围:
1.56-100U/mL
灵敏度:
0.39U/mL
特异性:
Natural and recombinant human Induced myeloid leukemia cell differentiation protein Mcl-1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
实验步骤:
实验步骤
研究领域:
Cancer
Human MCL1 ELISA Kit
规格 & 价格: cart
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Human MCL1 ELISA Kit
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产品说明书
数据表: 下载说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


精密度
批内差:已知浓度的3个样本在一个板子内重复检测20次,以评估批内精密度。
批内 CV: ≤4.5%
批间差:已知浓度的3个样本在不同的板子上重复测定5次,以评估测定批间精密度。
批间 CV: ≤7.6%
回收率
回收率:低、中和高浓度的分析物被掺入到血清或者血浆样本中,进行回收实验测定。

Sample Type

Average(%)

Recovery Range(%)

Serum

84

80-90

Plasma

86

80-92

 

 

 

 

线性
线性:给定样本通过梯度稀释,每次稀释的测量值与理论值的比值。

Sample

1:2

1:4

1:8

1:16

serum(n=5)

84-94%

107-119%

97-108%

101-110%

EDTA plasma(n=5)

106-116%

83-96%

103-113%

114-124%

heparin plasma(n=5)

97-106%

 

100-109%

88-98%

82-92%

 

通用注释


亚单元:
Interacts with HIF3A (via C-terminus domain) (By similarity). Interacts with BAD, BOK, BIK and BMF (By similarity). Interacts with PMAIP1 (PubMed:17389404). Interacts with BBC3 (By similarity). Isoform 1 interacts with BAX, BAK1 and TPT1 (PubMed:10837489, PubMed:12149273, PubMed:15077116). Heterodimer of isoform 1 and isoform 2. Homodimers of isoform 1 or isoform 2 are not detected. Isoform 2 does not interact with pro-apoptotic BCL2-related proteins (PubMed:10837489). Interacts with BOP (PubMed:23055042). Interacts with BCL2L11; may sequester BCL2L11 to prevent its pro-apoptotic activity (PubMed:10837489, PubMed:27013495, PubMed:17389404, PubMed:20562877).


功能:
Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.


亚细胞位置:
Membrane Single-pass membrane protein Cytoplasm Mitochondrion Nucleus Nucleoplasm Cytoplasmic, associated with mitochondria.


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