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IFNAR1 (基因名), Interferon alpha/beta receptor 1 (蛋白名), INAR1_HUMAN.
产品名称:

Human IFNAR1/ Interferon alpha/beta receptor 1 ELISA Kit
干扰素α/β受体1

货号:

E1425h

商标:
EIAab®
监管等级:
别名:

Cytokine receptor class-II member 1, Cytokine receptor family 2 member 1, Type I interferon receptor 1, CRF2-1, IFN-R-1, IFNAR

检测方法:
ELISA
实验类型:
Sandwich
检测范围:
0.156-10ng/mL
灵敏度:
0.034ng/mL
特异性:
Natural and recombinant human Interferon alpha/beta receptor 1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
实验步骤:
实验步骤
研究领域:
Immunology
Human IFNAR1 ELISA Kit
规格 & 价格: cart
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Human IFNAR1 ELISA Kit
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产品说明书
数据表: 下载说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


精密度
批内差:已知浓度的3个样本在一个板子内重复检测20次,以评估批内精密度。
批内 CV: ≤5.6%
批间差:已知浓度的3个样本在不同的板子上重复测定5次,以评估测定批间精密度。
批间 CV: ≤9.6%
回收率
回收率:低、中和高浓度的分析物被掺入到血清或者血浆样本中,进行回收实验测定。

Sample Type

Average(%)

Recovery Range(%)

Serum

101

95-107

Plasma

103

97-109

 

 

 

 

线性
线性:给定样本通过梯度稀释,每次稀释的测量值与理论值的比值。

Sample

1:2

1:4

1:8

1:16

serum(n=5)

100-110%

83-95%

88-97%

92-102%

EDTA plasma(n=5)

102-112%

96-105%

101-112%

107-117%

heparin plasma(n=5)

84-94%

 

82-94%

107-116%

112-122%

 

通用注释


亚单元:
Heterodimer with IFNAR2 (PubMed:7665574, PubMed:10049744, PubMed:21854986). Interacts with STAT1 and STAT2; the interaction requires its phosphorylation at Tyr-466 (PubMed:9121453). Interacts with TYK2 (PubMed:7526154, PubMed:15337770, PubMed:24704786). Interacts (serine-phosphorylated form) with FBXW11, the substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex (PubMed:14532120, PubMed:15337770, PubMed:18056411). Interacts with SHMT2; this promotes interaction with FAM175B and the BRISC complex (PubMed:24075985).


功能:
Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1 (PubMed:2153461, PubMed:7665574, PubMed:10049744, PubMed:14532120, PubMed:15337770, PubMed:21854986). Functions in general as heterodimer with IFNAR2 (PubMed:7665574, PubMed:10049744, PubMed:21854986). Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves (PubMed:7665574, PubMed:21854986). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway.


亚细胞位置:
Isoform 1 Cell membrane Single-pass type I membrane protein Late endosome Lysosome Interferon binding triggers internalization of the receptor from the cell membrane into endosomes and then into lysosomes.


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