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Glrx2 (基因名), Glutaredoxin-2, mitochondrial (蛋白名), GLRX2_RAT.
产品名称:

Rat Glrx2/ Glutaredoxin-2, mitochondrial ELISA Kit
线粒体谷阳换蛋白2

货号:

E12991r

商标:
EIAab®
监管等级:
别名:

Grx2

检测方法:
ELISA
特异性:
Natural and recombinant rat Glutaredoxin-2, mitochondrial
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
Cancer
Rat Glrx2 ELISA Kit
规格 & 价格: cart
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Rat Glrx2 ELISA Kit
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产品说明书
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通用注释


亚单元:
Monomer; active form. Homodimer; inactive form. The homodimer is probably linked by 1 2Fe-2S cluster.


功能:
Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release.


亚细胞位置:
Isoform 2 Nucleus


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