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BNIP3L (基因名), BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (蛋白名), BNI3L_HUMAN.
产品名称:

Human BNIP3L/ BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like ELISA Kit
BCL2/腺病毒E1B 19kda蛋白相互作用蛋白3样

货号:

E15459h

商标:
EIAab®
监管等级:
别名:

Adenovirus E1B19K-binding protein B5, BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A, NIP3-like protein X, NIP3L, BNIP3A, BNIP3H, NIX

检测方法:
ELISA
实验类型:
Sandwich
检测范围:
0.312-20ng/mL
灵敏度:
0.14ng/mL
特异性:
Natural and recombinant human BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
实验步骤:
实验步骤
研究领域:
Cancer
Human BNIP3L ELISA Kit
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Human BNIP3L ELISA Kit
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产品说明书
数据表: 下载说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


通用注释


亚单元:
Self-associates. Interacts with BNIP3 and STEAP3. Interacts with human adenovirus-2 E1B 19 kDa protein. Interacts (via BH3 domain) with SPATA18 (via coiled-coil domains).


功能:
Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. May function as a tumor suppressor.


亚细胞位置:
Nucleus envelope Endoplasmic reticulum Mitochondrion outer membrane Membrane Single-pass membrane protein Colocalizes with SPATA18 at the mitochondrion outer membrane.


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