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AIMP2 (基因名), Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (蛋白名), AIMP2_HUMAN.
产品名称:

Human AIMP2/ Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 ELISA Kit
氨酰tRNA合成酶络合作用多功能蛋白2

货号:

E2927h

商标:
EIAab®
监管等级:
别名:

Multisynthase complex auxiliary component p38, Protein JTV-1, PRO0992, JTV1

检测方法:
ELISA
实验类型:
Sandwich
检测范围:
0.156-10ng/mL
灵敏度:
0.375ng/mL
特异性:
Natural and recombinant human Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
实验步骤:
实验步骤
研究领域:
-
Human AIMP2 ELISA Kit
规格 & 价格: cart
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Human AIMP2 ELISA Kit
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产品说明书
数据表: 下载说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


通用注释


亚单元:
Component of the aminoacyl-tRNA synthase complex which is comprised of a bifunctional glutamyl-prolyl-tRNA synthase, the monospecific isoleucyl, leucyl, glutaminyl, methionyl, lysyl, arginyl and aspartyl-tRNA synthases, and three auxiliary proteins, EEF1E1/p18, AIMP2/p38 and AIMP1/p43. Binds FUBP1 (via C-terminus). Interacts in both its unphosphorylated and phosphorylated forms with p53/TP53 (via N-terminus) in the nucleus following UV irradiation. Interacts (via N-terminus) with KARS and PARK2/parkin (via first RING-type domain).


功能:
Required for assembly and stability of the aminoacyl-tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor.


亚细胞位置:
Cytoplasm Cytosol Nucleus Following DNA damage, dissociates from the aminoacyl-tRNA synthase complex and translocates from the cytoplasm to the nucleus.


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