Abcb1 (基因名), ATP-dependent translocase ABCB1 (蛋白名), mdr1_rat.
产品名称:
Rat Abcb1/ ATP-dependent translocase ABCB1 CLIA Kit
多药耐药蛋白1
货号:
U8039r
商标:
EIAab®
监管等级:
别名:
ATP-binding cassette sub-family B member 1, Multidrug resistance protein 1, P-glycoprotein 1, Phospholipid transporter ABCB1, CD243, Mdr1, Mdr1b, Pgy1
检测方法:
CLIA
实验类型:
Sandwich
检测范围:
39-2500pg/mL
特异性:
Natural and recombinant rat ATP-dependent translocase ABCB1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
Signal Transduction
通用注释
亚单元:
Interacts with PSMB5. Finds in a complex with ABCB1, TFPI2 and PPP2R3C; leading to the dephosphorylation of ABCB1.
功能:
Translocates drugs and phospholipids across the membrane. Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins. Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
亚细胞位置:
Cell membrane
Multi-pass membrane protein
Apical cell membrane
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