Htr3a (基因名), 5-hydroxytryptamine receptor 3A (蛋白名), 5HT3A_RAT.
Rat Htr3a/ 5-hydroxytryptamine receptor 3A CLIA Kit
5-HT3-A, 5-hydroxytryptamine receptor 3, 5-HT-3, Serotonin receptor 3A, Serotonin-gated ion channel receptor, 5ht3, Htr3
Natural and recombinant rat 5-hydroxytryptamine receptor 3A
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Interacts with RIC3 (By similarity). Forms pentahomomeric complex as well as pentaheteromeric complex with HTR3B; homomeric complex is functional but exhibits low conductance with modified voltage dependence and antagonist affinity.
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel.
Cell junction Synapse Postsynaptic cell membrane Multi-pass membrane protein Cell membrane Multi-pass membrane protein
MPLCIPQVLL | ALFLSVLIAQ | GEGSRRRATQ | AHSTTQPALL | RLSDHLLANY |
KKGVRPVRDW | RKPTLVSIDV | IMYAILNVDE | KNQVLTTYIW | YRQFWTDEFL |
QWTPEDFDNV | TKLSIPTDSI | WVPDILINEF | VDVGKSPSIP | YVYVHHQGEV |
QNYKPLQLVT | ACSLDIYNFP | FDVQNCSLTF | TSWLHTIQDI | NISLWRTPEE |
VRSDKSIFIN | QGEWELLGVF | TKFQEFSIET | SNSYAEMKFY | VVIRRRPLFY |
AVSLLLPSIF | LMVVDIVGFC | LPPDSGERVS | FKITLLLGYS | VFLIIVSDTL |
PATAIGTPLI | GVYFVVCMAL | LVISLAETIF | IVQLVHKQDL | QRPVPDWLRH |
LVLDRIAWLL | CLGEQPMAHR | PPATFQANKT | DDCSAMGNHC | SHVGSPQDLE |
KTSRSRDSPL | PPPREASLAV | RGLLQELSSI | RHSLEKRDEM | REVARDWLRV |
GYVLDRLLFR | IYLLAVLAYS | ITLVTLWSIW | HYS
"A cytoplasmic region determines single-channel conductance in 5-HT3 receptors."
"Association between a polymorphism of the HTR3A gene and therapeutic response to risperidone treatment in drug-naive Chinese schizophrenia patients."
"Distinguishable haplotype blocks in the HTR3A and HTR3B region in the Japanese reveal evidence of association of HTR3B with female major depression."
"Cell surface expression of 5-hydroxytryptamine type 3 receptors is promoted by RIC-3."
"Mutational analysis of serotonin receptor genes: HTR3A and HTR3B in fibromyalgia patients."
"A polymorphism in the serotonin receptor 3A (HTR3A) gene and its association with harm avoidance in women."
"Novel mutations in 5-HT3A and 5-HT3B receptor genes not associated with clozapine response."
"Molecular cloning of human 5-hydroxytryptamine3 receptor: heterogeneity in distribution and function among species."
"Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study."
"Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol?"
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