Irs1 (基因名), Insulin receptor substrate 1 (蛋白名), irs1_rat.
产品名称:
Rat Irs1/ Insulin receptor substrate 1 CLIA Kit
胰岛素受体底物1
货号:
U1660r
商标:
EIAab®
监管等级:
别名:
pp185, IRS-1, Irs-1
检测方法:
CLIA
实验类型:
Sandwich
检测范围:
39-2500pg/mL
特异性:
Natural and recombinant rat Insulin receptor substrate 1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
Cancer
通用注释
亚单元:
Interacts with SOCS7 (By similarity). Interacts (via IRS-type PTB domain) with IGF1R and INSR (via the tyrosine-phosphorylated NPXY motif) (By similarity). Interacts with UBTF, FER and PIK3CA (By similarity). Interacts (via phosphorylated YXXM motifs) with PIK3R1. Interacts with ROCK1. Interacts (via PH domain) with PHIP. Interacts with GRB2. Interacts with ALK (By similarity). Interacts with EIF2AK2/PKR.
功能:
May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit.
亚细胞位置:
N/A
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