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COL2A1 (基因名), Collagen alpha-1(II) chain (蛋白名), co2a1_human.
产品名称:

Human COL2A1/ Collagen alpha-1(II) chain Recombinant Protein
胶原蛋白alpha -(2)链

货号:

R0572h

商标:
EIAab®
监管等级:
别名:

Alpha-1 type II collagen

序列号:
P02458
来源:
E.coli
种属:
Human
标签:
His
序列:
23-268aa
预估分子量:
27.06 kDa (monomer)
纯度:
Greater than 95% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Signal Transduction
  • Human COL2A1 Protein
  • Human COL2A1 Protein
  • Human COL2A1 Protein
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Human COL2A1 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
Human COL2A1 Protein
The PCR product of human COL2A1 gene was determined by 1% Agarose stained with EB.
Human COL2A1 Protein
Recombinant human COL2A1 protein was determined by 12% SDS-PAGE stained with Coomassie Blue under reducing conditions.
基因位点
Cytogenetic band: 12q13.11 by HGNC 12q13.11 by Entrez Gene 12q13.11 by Ensembl
COL2A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Homotrimers of alpha 1(II) chains.


功能:
Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces.


亚细胞位置:
Secreted Extracellular space Extracellular matrix



[1].
"A COL2A1 gene polymorphism is related with advanced stages of osteoarthritis of the knee in Mexican Mestizo population."

[2].
"COL1A1 and COL2A1 genes and myopia susceptibility: evidence of association and suggestive linkage to the COL2A1 locus."

[3].
"COL2A1 gene polymorphisms and susceptibility to osteoarthritis of the hand in Finnish women."

[4].
"Perthes' disease and the search for genetic associations: collagen mutations, Gaucher's disease and thrombophilia."

[5].
"Genetic and epigenetic factors at COL2A1 and ABCA4 influence clinical outcome in congenital toxoplasmosis."

[6].
"Missense and nonsense mutations in the alternatively-spliced exon 2 of COL2A1 cause the ocular variant of Stickler syndrome."

[7].
"A familial case of achondrogenesis type II caused by a dominant COL2A1 mutation and "patchy" expression in the mosaic father."

[8].
"Sex and ethnic differences in the association of ASPN, CALM1, COL2A1, COMP, and FRZB with genetic susceptibility to osteoarthritis of the knee."

[9].
"High efficiency of mutation detection in type 1 stickler syndrome using a two-stage approach: vitreoretinal assessment coupled with exon sequencing for screening COL2A1."

[10].
"A novel mutation of COL2A1 resulting in dominantly inherited rhegmatogenous retinal detachment."
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