Abstract
Purpose: To evaluate whether fibroblast growth factor-23 (FGF-23) has a common role in the pathogenesis of peripheral arterial disease (PAD) and chronic kidney disease (CKD) in type-2 diabetes mellitus (DM).
Material and Method: Twenty-one patients with diabetic nephropathy composed the diabetic nephropathy (DM-NP) group and 20 subjects with DM but without NP constituted the DM group. The control group was comprised of 10 age- and gender-matched non-diabetic individuals with CKD. Results: FGF-23 levels were similar in DM-NP and CKD groups (p=0.5). Both groups had higher FGF-23 levels compared to DM group (p Discussion: NP and PAD may be independent complications of DM. In DM, FGF-23 may be a marker of NP but not of PAD.
Keywords: Diabetes mellitus, fibroblast growth factor-23, nephropathy, peripheral arterial disease, atherosclerosis, arterial calcification