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Home > Citations> Interleukin‐1 receptor antagonist correlates with hepatic venous pressure gradient and predicts occurrence of overall complications and bacterial infe
Interleukin‐1 receptor antagonist correlates with hepatic venous pressure gradient and predicts occurrence of overall complications and bacterial infe

 

Abstract

Aims

The plasma levels of interleukin (IL)-1α, IL-1β and IL-1 receptor antagonist (IL-1Ra) are increased in cirrhotic patients. We aimed to investigate whether these cytokines correlate with hepatic venous pressure gradient (HVPG), the severity of liver cirrhosis and complications of cirrhosis.

Methods

Sixty-three cirrhotic patients that underwent hemodynamic studies in Taipei Veterans General hospital were enrolled retrospectively. Plasma levels of IL-1α, IL-1β, IL-1Ra and endotoxin were assessed by enzyme-linked immunosorbent assay. Plasma obtained from 11 healthy subjects served as normal controls.

Results

Plasma levels of IL-1α, IL-1β and IL-1Ra were increased in cirrhotic patients compared with controls (3.84 ± 2.17 pg/ml, 1.53 ± 1.56 pg/ml, 854.97 ± 396.29 pg/ml vs. 0, 0, 411.70 ± 100.32 pg/ml, respectively). IL-1Ra levels significantly correlated with plasma endotoxin levels (r=0.329, p=0.008), Child-Pugh scores (r=0.421, p=0.001), Model of end-stage liver disease (MELD) scores (r=0.343, p=0.006) and HVPG (r=0.385, p=0.002). On multivariate analysis, higher IL-1Ra levels (≥760 pg/ml) predicted the occurrence of portal hypertension related complications [hazard ratio (HR): 3.001; 95% confidence interval (CI): 1.484-6.071; p=0.002] and the development of bacterial infections (HR: 2.054; 95% CI: 1.081-3.903; p=0.028) independently of the MELD scores and portal pressure. Furthermore, higher IL-1Ra levels also predicted the survival in patients without hepatocellular carcinoma (HR: 15.143; 95% CI: 2.884-79.509; p=0.001).

Conclusions

The plasma IL-1Ra level correlates with HVPG. Additionally, it may predict the occurrence of portal hypertension related complications and bacterial infections in cirrhotic patients and the survival in patients without hepatocellular carcinoma.

Cited products
Source:hepatology research     by YC Hsieh, KC Lee, YY Yang, et al.
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